At the start of each game, the player selects two characters with each character having different statistics such as health, attack, defense power, and movement speed, as well as a number of abilities. The game is based on directing the survivors of a prison spacecraft (crew, prisoners, and civilians alike), having crash-landed on a strange alien planet, through several levels as to achieve escape from the planet. Dungeon of the Endless is a roguelike game, featuring procedurally generated levels and the notion of permadeath, so that each runthrough of the game is different.